Pharmaceutical compositions containing camptothecins
AssigneeKabushiki Kaisha Yakult Honsha
InventorsMasako Nakazawa, Ritsuo Aiyama, Masato Nagaoka
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Abstract
A camptothecin-containing pharmaceutical composition which contains: (a) camptothecin or a derivative thereof, and (b) one or more compounds selected from among ascorbic acid or a salt thereof, sodium hydrogen sulfite, sodium sulfite, potassium pyrosulfite, sodium erythorbate, sodium thioglycolate, sodium pyrosulfite, and α-thioglycerin. The pharmaceutical composition is useful in that, after storage for a long period of time or under light-irradiation conditions, camptothecin or a derivative thereof contained therein undergoes minimum degradation.
Claims17
A camptothecin-containing pharmaceutical composition comprising:
- (a) camptothecin or a derivative thereof, and (b) one or more compounds selected from among ascorbic acid or a salt thereof, sodium hydrogen sulfite, sodium sulfite, potassium pyrosulfite, sodium erythorbate, sodium thioglycolate, sodium pyrosulfite, and α-thioglycerin.
A method for preventing degradation of camptothecin or a derivative thereof, comprising adding, to a composition containing camptothecin or a derivative thereof, one or more compounds selected from among ascorbic acid or a salt thereof, sodium hydrogen sulfite, sodium sulfite, potassium pyrosulfite, sodium erythorbate, sodium thioglycolate, sodium pyrosulfite, and α-thioglycerin.
Dependencies are inferred from the claim text.