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US 2006/0235039 A1Published application
Hydromorphone polymorphs
AssigneeNoramco, Inc.
InventorsKeith Lorimer, Alicia Ng
Life of this patent
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Abstract
Hydromorphone hydrochloride forms are disclosed which are useful as analgesic agents either in combination with or as replacements for hydromorphone hydrochloride.
Claims22
A form of hydromorphone hydrochloride selected from the group consisting of forms B, C, D and an amorphous form.
A process for making hydromorphone hydrochloride Form B, which comprises:
- dissolving hydromorphone hydrochloride in a solvent selected from water or 4:1 (v/v) tetrahydrofuran:water mix, filtering the solution, and evaporating to dryness under ambient conditions to yield the Form B.
A process for making hydromorphone hydrochloride Form C, which comprises:
- dissolving hydromorphone hydrochloride in acetonitrile:water mix, filtering the solution and evaporating to dryness at an elevated temperature to yield the Form C.
A process for making hydromorphone hydrochloride Form D, which comprises:
- dissolving hydromorphone hydrochloride in a solvent selected from water, ethanol:water:methanol mix or acetone:water mix, filtering the solution, and evaporating to dryness under ambient conditions to yield the Form D.
A process for making an amorphous form of hydromorphone hydrochloride, which comprises:
- dissolving hydromorphone hydrochloride in water, filtering the solution and evaporating to dryness under reduced temperature and reduced pressure to yield the amorphous form.
Dependencies are inferred from the claim text.