Heterocyclic inhibitors of protein arginine methyl transferases

A compound of formula I, or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof,

• wherein:
• Ring Q is
• bond (a) is an optional double or single bond;
• X is C (i.e., carbon) or N (i.e., nitrogen);
• Y is NH, N-Me, or CH;
• Z is N-R6, O, or S, where R6 is C1-C6 alkyl;
• wherein when bond (a) is a single bond, X is —CR—, R is indenpendently H or C1-4 alkyl and CR2 is H or C1-4 alkyl;
• alternatively, R2 and R may join to form a 3-6 membered cycloalkyl ring;
• A, B and D are each independently N or C, in which C may be optionally substituted with H, Me, Et, halogen, CN, NO2, OMe, OEt, SMe, SO2Me, CF3, or OCF3;
• R1 is aryl, substituted aryl, aryalkyl, heterocycle, or substituted heterocycle;
• R2 is H, Me, Et, halogen, CN, NO2, OMe, OEt, SMe, SO2Me, CF3, or OCF3, provided that when X is N, R2 is nil;
• R3 is H or C1-C4 alkyl;
• and
• R4 is independently H or C1-4 alkyl;
• R5 is independently H, C1-4 alkyl;
• alternatively, R5 and R3 may join to form a 4, 5, or 6 membered saturated ring containing one N;
• and
• n is 1, 2, or 3.