Novel compounds for treatment of cancer and disorders associated with angiogenesis function
OwnerNouri Neamatiinventor
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Abstract
Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating cell growth, cell cycle, apoptosis, or gene expression.
Claims11
A compound of any of Formulas 1-19,
- Formula 1
- Formula 2
- Formula 3
- Formula 4
- Formula 5
- Formula 6
- Formula 7
- Formula 8
- Formula 9
- Formula 10
- Formula 11
- Formula 12
- Formula 13
- Formula 14
- Formula 15
- Formula 16
- Formula 17
- Formula 18
- Formula 19
- wherein each of R1, R2, and R3 is a hydrogen, halogen, hydroxyl, alkyl, substituted alkyl, alkenyl, substituted alkenyl, phenyl, substituted phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, or an organic group containing 1-20 carbon atoms in a linear, branched, or cyclic structural format.
A compound selected from the group consisting of SC20-37, SC201-266, SC268, and SC270-280.
Dependencies are inferred from the claim text.