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AssigneeAvanir Pharmaceuticals
InventorsFederice Gaeta, Andrew Baird, Jerry Anchin, Wenbin Ying, Robert Florkiewicz, Jagadish Sircar, Sunil K.C.
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Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
A pharmaceutical composition for treating a disease or disorder wherein macrophage migration inhibitory factor is pathogenic, the pharmaceutical composition comprising a macrophage migration inhibitory factor inhibiting compound and a drug for treating the disease or disorder, wherein the drug has no measurable macrophage migration inhibitory factor inhibiting activity.
A pharmaceutical composition for treating a disease or disorder wherein macrophage migration inhibitory factor is pathogenic, the pharmaceutical composition comprising a macrophage migration inhibitory factor inhibiting compound and a drug selected from the group consisting of nonsteroidal anti-inflammatory drug, anti-infective drug, beta stimulant, steroid, antihistamine, anticancer drug, asthma drug, sepsis drug, arthritis drug, and immunosuppresive drug.
Dependencies are inferred from the claim text.