US 2006/0235016 A1 · Morpholine Dopamine Agonists

Abstract

The present invention provides for compounds of formula (I), (Ia) and (Ib) Wherein: A is selected from C—X and N, B is selected from C—Y and N, R1 is selected from H and (C1-C6)alkyl, R2 is selected from H and (C1-C6)alkyl, X is selected from H, HO, C(O)NH2, NH2 Y is selected from H, HO, NH2, Br, Cl and F Z is selected from H, HO F, CONH2 and CN; And pharmaceutically acceptable salts, solvates and prodrugs thereof; With the provisos that: for a compound of formula (I), (Ia) or (Ib), when A is C—X, B is C—Y, R1 is H or (C1-C6)alkyl and R2 is H or (C1-C6)alkyl at least one of X, Y and Z must be OH; for a compound of formula (I), when A is C—X and B is C—Y, Y is H, Z is H, R1 is H and R2 is H, then X cannot be OH; these compounds are useful as a medicament.

Claims24

Dependent claims

Compounds of formula (Ia) and (Ib)

Wherein:
A is C—X,
B is selected from C—Y and N,
R1 is selected from H and (C1-C6)alkyl,
R2 is selected from H and (C1-C6)alkyl,
X is selected from H, HO, C(O)NH2, NH2
Y is selected from H, HO, NH2, Br, Cl and F
Z is selected from H, HO F, CONH2 and CN;
And pharmaceutically acceptable salts, solvates and prodrugs thereof;
With the provisos that:
for a compound of formula (Ia) or (Ib), when B is C—Y, at least one of X, Y and Z must be OH.

8 more elements

Dependencies are inferred from the claim text.

Morpholine Dopamine Agonists

Life of this patent

Morpholine Dopamine Agonists

Life of this patent

Abstract

Claims24