7-Phenyl pyrazolopyridine compounds
AssigneeEisai Co.Ltd.
InventorsShigeki Hibi, Yorihisa Hoshino, Koichi Kikuchi, Kyogyoku Shin, Yoshinori Takahashi, Masae Fujisawa, Hisashi Shibata, Mitsuhiro Ino
Life of this patent
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Abstract
A compound represented by the formula: [wherein R1 is methoxy, methylthio, ethyl, etc.; R5 and R6 are each independently cyclopropylmethyl, (4-tetrahydropyranyl)methyl, etc.; and two of R40, R41 and R42 are C1-6 alkoxy while the remaining one is methoxymethyl, etc.], a salt thereof, or a hydrate of the foregoing. This compound has excellent antagonism against corticotropin-releasing factor receptor.
Claims24
A compound represented by the formula:
- [wherein R1 is a group represented by the formula -G1z-R1z (wherein G1z is a single bond, oxygen or sulfur, and R1z is methyl or ethyl) or methoxymethyl;
- R5 and R6 are each independently hydrogen, t-butoxycarbonyl or a group represented by the formula —X6b—X7b (wherein X6b is methylene and X7b is C1-6 alkyl, C3-8 cycloalkyl, tetrahydropyran-yl or tetrahydrofuran-yl);
- and two of R40, R41 and R42 are C1-6 alkoxy while the remaining one is a group represented by the formula —V1a—V2a (wherein V1a is a single bond, —CO—, C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene, and V2a is hydrogen, hydroxyl, C1-6 alkyl optionally substituted with 1 to 3 substituents selected from Substituent Group B below, C1-6 alkoxy optionally substituted with 1 to 3 substituents selected from Substituent Group B below, a group represented by —N(R3c)R3d (wherein R3c and R3d are each independently hydrogen or C1-6 alkyl optionally substituted with 1 to 3 substituents selected from Substituent Group B below), methanesulfonyloxy, p-toluenesulfonyloxy, pyrrolidinyl, piperazinyl, piperidyl, morpholinyl, C3-8 cycloalkyl, tetrahydropyran-yl or tetrahydrofuran-yl),
- wherein Substituent Group B is the group consisting of fluorine atom, chlorine atom, bromine atom, cyano, C1-6 alkoxy, pyrrolidinyl, piperazinyl, piperidyl, morpholinyl, C3-8 cycloalkyl, tetrahydropyran-yl and tetrahydrofuran-yl],
- a salt thereof or a hydrate of the foregoing.
A compound represented by the formula:
- [wherein R5t and R6t are each independently cyclopropylmethyl, (4-tetrahydropyranyl)methyl, (3-tetrahydrofuranyl)methyl or (2-tetrahydrofuranyl)methyl;
- R1t is methoxy, methylthio, methyl, ethyl or methoxymethyl;
- and
- R43t is C1-6 alkyl],
- a salt thereof or a hydrate of the foregoing.
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Dependencies are inferred from the claim text.