Inhibitors of Papilloma Virus

A compound of formula (I) or an enantiomer or diastereoisomer thereof:

• wherein:
• A is a 5- or 6-membered carbocyclic ring;
• X is H and W is OH;
• or X and W together form a carbonyl group or an epoxide;
• R1 is H;
• or one or two substituents independently selected from the group consisting of:
• hydroxy;
• halo;
• lower alkyl;
• lower alkoxy;
• lower thioalkyl;
• haloalkyl (e.g. trifluoromethyl);
• or —C(O)R2 wherein R2 is lower alkyl aryloxy or benzyloxy;
• Y is phenyl optionally mono- or di-substituted with R5 or C(O)R6, wherein R5 is lower alkyl lower cycloalkyl, lower alkoxy, halo, hydroxy, nitrile or trifluoromethyl, and R6 is lower alkyl lower cycloalkyl, lower alkoxy, hydroxy or trifluoromethyl;
• said phenyl ring being optionally fused with a saturated or unsaturated 4 to 6-membered carbocyclic ring;
• or Y is ethylene-phenyl, said ethylene moiety being optionally mono-substituted with lower alkyl wherein said phenyl ring is optionally mono- or di-substituted with R5 or C(O)R6, wherein R5 and R6 are as defined above;
• said phenyl ring being optionally fused with a saturated or unsaturated 4 to 6-membered carbocyclic ring;
• R3 is selected from the group consisting of:
• lower alkyl lower cycloalkyl, lower alkylene, aryl or lower aralkyl, all of which optionally mono- or di-substituted with:
• lower alkyl lower cycloalkyl, haloalkyl, halo, CN, azido, lower alkoxy, (lower alkyl)acyl, C1-6 thioalkyl, C1-6 alkylsulfonyl, NHC(O)-lower alkyl NHC(O)-aryl, NHC(O)—O-lower alkyl NHC(O)O-aryl, aryl, aryloxy, hydroxy, nitro, amino, or Het, said Het optionally mono- or di-substituted with lower alkyl lower cycloalkyl, lower alkoxy, halo, hydroxy, nitrile trifluoromethyl, C(O)R6 wherein R6 is as defined above;
• provided that when R3 is aryl mono- or disubstituted with Het, Het is not optionally substituted morpholine or an optionally substituted five-membered, unsaturated heterocycle containing from one to three heteroatoms selected from nitrogen, oxygen and sulfur;
• said lower cycloalkyl, aryl, lower aralkyl or Het being optionally fused with a saturated or unsaturated 4 to 6-membered ring optionally containing a heteroatom selected from N, O and S;
• and
• R4 is a carboxylic acid, a salt or an ester thereof;
• and with the provisos that:
• (1) when A is benzene, R1 is hydrogen, X and W together form a carbonyl group and Y is 4-methylphenyl, then R3 cannot be benzyl, 3-fluorophenyl, or 4-nitrophenyl;
• (2) when A is benzene, R1 is hydrogen, X and W together form a carbonyl group and R3 is cyclohexyl, then Y cannot be 4-iodophenyl or 4-methylphenyl;
• (3) when A is benzene, R1 is hydrogen, X and W together form a carbonyl group and Y is 4-fluorophenyl, then R3 cannot be 4-ethyloxycarbonylphenyl;
• (4) when A is benzene, R1 is hydrogen, X and W together form a carbonyl group and Y is 2-methylphenyl then R3 cannot be 4-nitrophenyl;
• (5) when A is benzene, R1 is hydrogen, X and W together form a carbonyl group and Y is 2-methylphenyl, then R3 cannot be phenyl or 2-bromo-4-methylphenyl;
• (6) when A is benzene, R1 is hydrogen, X and W together form a carbonyl group and Y is 4-chlorophenyl, then R3 cannot be 2-methoxyphenyl;
• (7) when A is benzene, R1 is hydrogen, X and W together form a carbonyl group and Y is 4-ethylphenyl, then R3 cannot be 3-fluorophenyl;
• and
• (8) when A is benzene, R1 is hydrogen, X and W together form a carbonyl group and Y is phenyl, then R3 cannot be phenyl.