Treatment of vascular, autoimmune and inflammatory diseases using low dosages of IMPDH inhibitors
OwnerRichard Glickman, Michael Hayden +1inventors
InventorsRichard Glickman, Michael Hayden, Noel Hall
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Abstract
The disclosure provides methods and compositions for treating a vascular, autoimmune, and/or inflammatory disease, or a condition associated therewith, with a dose of an inosine monophosphate dehydrogenase (IMPDH) inhibitor effective to treat the vascular, autoimmune and/or inflammatory disease, or associated condition but that does not produce immunosuppression sufficient to reduce the risk of allograft rejection. These lower doses of the immunosuppressant avoid the adverse consequences of severe immunosuppression while providing effective treatment of the vascular, autoimmune and/or inflammatory disease.
Claims21
A method of treating a vascular, autoimmune and/or inflammatory disease, or a condition associated therewith, comprising administering to a human subject an amount of an IMPDH inhibitory compound selected from MPA, MMF, and combinations thereof that is effective to treat or reduce the risk of the vascular, autoimmune and/or inflammatory disease, or a condition associated therewith, but that does not produce immunosuppression sufficient to reduce the risk of allograft rejection.
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and an amount of an IMPDH inhibitory compound selected from MPA, MMF, and combinations thereof that is effective to achieve a low, extra-low or ultra-low daily dose when taken once or more per day.
Dependencies are inferred from the claim text.