Aromatic oxyphenyl and aromatic sulfanylphenyl derivatives

A compound of the formula I

• wherein
• X is O, S or CR11R12, wherein R11 and R12 are each independently H or C1-6 alkyl;
• Y is O or S;
• R1, R2, R3 and R4 are each independently hydrogen;
• halogen;
• cyano;
• nitro;
• C1-6-alk(en/yn)yl;
• C1-6-alk(en/yn)yloxy;
• C1-6-alk(en/yn)ylsulfanyl;
• hydroxy;
• hydroxy-C1-6-alk(en/yn)yl;
• halo-C1-6-alk(en/yn)yl;
• halo-C1-6-alk(en/yn)yloxy;
• C3-8-cycloalk(en)yl;
• C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl;
• acyl;
• C1-6-alk(en/yn)yloxycarbonyl;
• C1-6-alk(en/yn)ylsulfonyl;
• aryl optionally substituted with a halogen, cyano, nitro, C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yloxy, C1-6-alk(en/yn)ylsulfanyl, hydroxy, hydroxy-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yloxy, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, acyl, C1-6-alk(en/yn)yloxycarbonyl or C1-6-alk(en/yn)ylsulfonyl;
• monocyclic heteroaryl optionally substituted with a halogen, cyano, nitro, C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yloxy, C1-6-alk(en/yn)ylsulfanyl, hydroxy, hydroxy-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yloxy, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, acyl, C1-6-alk(en/yn)yloxycarbonyl or C1-6-alk(en/yn)ylsulfonyl;
• or —NR13R14 wherein R13 and R14 are each independently hydrogen, C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6 alk(en/yn)yl or aryl, or R13 and R14 together with the nitrogen atom to which they are attached form a 3-7-membered heterocyclic ring which optionally contains one further heteroatom selected from O, S and N;
• R5 is aryl or monocyclic heteroaryl, optionally substituted with a halogen, cyano, nitro, C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yloxy, C1-6-alk(en/yn)ylsulfanyl, hydroxy, hydroxy-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yloxy, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, acyl, C1-6-alk(en/yn)yloxycarbonyl, C1-6-alk(en/yn)ylsulfonyl or —NR15R16 wherein R15 and R16 are each independently hydrogen, C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6 alk(en/yn)yl or aryl, or R15 and R16 together with the nitrogen atom to which they are attached form a 3-7-membered heterocyclic ring which optionally contains one further heteroatom selected from O, S and N;
• R6 is H, C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yloxy, C1-6-alk(en/yn)ylsulfanyl or C3-8-cycloalk(en)yl, provided that when R6 is C1-6-alk(en/yn)yloxy or C1-6-alk(en/yn)ylsulfanyl then X is CR11R12, wherein R11 and R12 are each independently H or C1-6 alkyl;
• R7 and R8 are each independently H, C1-6-alk(en/yn)yl or C3-8-cycloalk(en)yl;
• R9 and R9′ are each independently H, C1-6-alk(en/yn)yl, hydroxy-C1-6-alk(en/yn)yl, C1-6alk(en/yn)ylsulfanyl-C1-6-alk(en/yn)yl or C3-8-cycloalk(en)yl;
• or
• R6 and R8 together with the atoms to which they are attached and the intervening carbon atom form a saturated 3-7 membered heterocyclic ring, and R7 is H, C1-6-alk(en/yn)yl or C3-8-cycloalk(en)yl, and R9 and R9′ are each independently H, C1-6 alk(en/yn)yl, hydroxy-C1-6-alk(en/yn)yl, C1-6 alk(en/yn)ylsulfanyl-C1-6-alk(en/yn)yl or C3-8-cycloalk(en)yl;
• or
• R7 and R8 together with the atoms to which they are attached form a saturated 3-7 membered heterocyclic ring, and R6 is H, C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yloxy, C1-6-alk(en/yn)ylsulfanyl or C3-8-cycloalk(en)yl, provided that when R6 is C1-6 alk(en/yn)yloxy or C1-6-alk(en/yn)ylsulfanyl then X is CR11R12, wherein R11 and R12 are each independently H or C1-6 alkyl, and R9 and R9′ are each independently H, C1-6-alk(en/yn)yl, hydroxy-C1-6-alk(en/yn)yl, C1-6 alk(en/yn)ylsulfanyl-C1-6-alk(en/yn)yl or C3-8-cycloalk(en)yl;
• or
• R8 and R9 together with the atoms to which they are attached and the intervening carbon atom form a saturated 3-7 membered heterocyclic ring, and R6 is H, C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yloxy, C1-6-alk(en/yn)ylsulfanyl or C3-8-cycloalk(en)yl, provided that when R6 is C1-6-alk(en/yn)yloxy or C1-6-alk(en/yn)ylsulfanyl then X is CR11R12, wherein R11 and R12 are each independently H or C1-6 alkyl, and R7 is H, C1-6-alk(en/yn)yl or C3-8-cycloalk(en)yl, and R9′ is H, C1-6-alk(en/yn)yl, hydroxy-C1-6-alk(en/yn)yl, C1-6 alk(en/yn)ylsulfanyl-C1-6-alk(en/yn)yl or C3-8-cycloalk(en)yl;
• R10 is H, C1-6-alk(en/yn)yl, aryl, aryl-C1-6-alk(en/yn)yl, wherein aryl is optionally substituted with a halogen, CF3, OCF3, CN, NO2 or C1-6-alk(en/yn)yl, or an alkali metal;
• or a pharmaceutically acceptable salt thereof.