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US 2006/0234996 A1Published application
Novel crystalline form of ezetimibe and processes for the preparation thereof
OwnerItai Adin, Carmen Iustaininventors
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Abstract
A novel crystalline form of Ezetimibe and processes for the preparation thereof are disclosed.
Claims19
A crystalline solid comprising Ezetimibe Form E1 characterized by powder X-ray diffraction substantially as depicted in FIG. 2, with diffraction peaks at 7.9, 9.7, 12.0, 13.9, 14.7, 15.2, 15.7, 17.2, 18.6, 19.3, 19.8, 20.9, 21.2, 21.7, 22.7, 22.8, 23.4, 24.5, 25.3, 26.3, 27.0, 27.4, 28.2, 28.8, 29.5 and 30.0±0.2 degrees 2θ.
A process for preparing the crystalline Ezetimibe Form E1, comprising:
- a) dissolving Ezetimibe in an organic solvent;
- b) heating the mixture to reflux;
- c) cooling for sufficient time to enable crystallization;
- and
- d) collecting the crystals by filtration and drying, optionally at elevated temperature.
2 more elements
Dependencies are inferred from the claim text.