DHEA composition and method
AssigneeGenelabs Technologies, Inc.
InventorsJagdish Parasrampuria, Maxine Yonker, Kenneth Schwartz, Marc Gurwith
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Abstract
Disclosed are improved pharmaceutical formulations comprising dehydroepiandrosterone (DHEA), enriched in selected polymorphic forms, for therapeutic applications. In one embodiment, the formulation comprises, in solid form, DHEA, at least 85% of which is present as a single polymorph selected from the form I polymorph or the form II polymorph, and at least one pharmaceutical excipient. Methods for making and using such compositions are also disclosed.
Claims15
1-10. (canceled)
In a method for administering dehydroepiandrosterone (DHEA) to obtain an ameliorative result, the improvement comprising administering a pharmaceutically acceptable amount of DHEA, wherein at least 85% of the DHEA is present as the form I polymorph.
A pharmaceutical formulation comprising dehydroepiandrosterone (DHEA), at least 85% of which is present as the form II polymorph, and at least one pharmaceutical excipient.
19-21. (canceled)
A method for preparing a solid DHEA formulation, said method comprising:
- mixing at least one solid pharmaceutical excipient with dehydroepiandrosterone (DHEA), at least 85% of which is present as the form II polymorph.
23-27. (canceled)
In a method for administering dehydroepiandrosterone (DHEA) to obtain an ameliorative result, the improvement comprising administering a pharmaceutically acceptable amount of DHEA, wherein at least 85% of the DHEA is present as the form II polymorph.
29-34. (canceled)
A method for controlling the bioavailability of a DHEA formulation, the method comprising:
- administering to a subject a DHEA formulation comprising DHEA and a pharmaceutical excipient, wherein said DHEA in said formulation consists of a preselected, known ratio of DHEA polymorphs.
Dependencies are inferred from the claim text.