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US 2006/0234988 A1Published application
7-N-substituted phenyl tetracycline compounds
AssigneeTrustees of Tufts College
InventorsMark Nelson, Darrell Koza
Life of this patent
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Abstract
7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
Claims48
A 7-substituted tetracycline compound of the formula:
- wherein:
- R4 and R4′ are each alkyl;
- R5 is hydrogen, hydroxyl, or a prodrug moiety;
- R6 and R6′ are each independently hydrogen, hydroxyl, alkyl, or taken together, alkenyl;
- R7 is an N-substituted phenyl;
- and pharmaceutically acceptable salts thereof, and pharmaceutically acceptable salts thereof.
3 more elements
A method for treating a tetracycline responsive state in a mammal, comprising administering to said mammal a 7-substituted tetracycline compound of formula (I):
- wherein:
- R4 and R4′ are each alkyl;
- R5 is hydrogen, hydroxyl, or a prodrug moiety;
- R6 and R6′ are each independently hydrogen, hydroxyl, alkyl, or taken together, alkenyl;
- R7 is an N-substituted phenyl;
- and pharmaceutically acceptable salts thereof, such that the tetracycline responsive state is treated.
3 more elements
Dependencies are inferred from the claim text.