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US 2006/0234979 A1Published application
Aripiprazole complex formulation and method
AssigneeBristol-Myers Squibb Company
InventorsManoj Nerurkar, Vijay Naringrekar
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Abstract
An aripiprazole formulation is provided which includes the antipsychotic agent aripiprazole in the form of an inclusion complex in a β-cyclodextrin, preferably, sulfobutyl ether β-cyclodextrin (SBECD), which in the form of an injectable produces reversible generally minimal to mild irritation at the intramuscular injection site. A method for minimizing or reducing irritation caused by aripiprazole at an intramuscular injection site and a method for treating schizophrenia employing the above formulation are also provided.
Claims9
1-24. (canceled)
An aqueous injectable formulation comprising
- a) a complex comprising aripiprazole and sulfobutyl ether-β-cyclodextrin;
- b) tartaric acid;
- c) sodium hydroxide;
- and
- d) water for injection.
2 more elements
Dependencies are inferred from the claim text.