2,6-Dihalogeno-8-substituent-purine compound and process for producing the same
AssigneeSumitomo Chemical Company, Limited
InventorsAndrás Kotschy, András Nagy, A. Biro
Life of this patent
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Abstract
The present invention relates to a compound represented by the formula (1): wherein wherein X1 and X2 are each independently a halogen atom, is a single bond or a double bond, and R1, R2 and Z are each as defined in the description, or a salt thereof, a production method thereof and the like. A 2,6-dihalogeno-8-substituted-purine compound or a salt thereof, which is useful as an intermediate for producing medicaments, can be conveniently produced from a 2,6-dihalogenopurine compound or a salt thereof, and a 2,6-dihalogeno-8-substituted-purine compound or a salt thereof can be easily provided.
Claims23
A compound represented by the formula (2):
- wherein
- wherein X1 and X2 are each independently a halogen atom,
- R1 is an alkenyl group optionally having substituent(s), an alkynyl group optionally having substituent(s), an aryl group optionally having substituent(s) or a heteroaryl group optionally having substituent(s), and
- Z is a sugar group,
- or a salt thereof.
(canceled)
A compound represented by the formula (3):
- wherein
- wherein X1 and X2 are each independently a halogen atom,
- R1 is an alkyl group optionally having substituent(s), an alkenyl group optionally having substituent(s), an alkynyl group optionally having substituent(s), an aryl group optionally having substituent(s) or a heteroaryl group optionally having substituent(s),
- R2′ is a hydrogen atom, an alkyl group optionally having substituent(s), an alkenyl group optionally having substituent(s), an alkynyl group optionally having substituent(s), an aryl group optionally having substituent(s) or a heteroaryl group optionally having substituent(s), and
- Z is an amino-protecting group, a sugar group or an alkyl group, or a salt thereof.
A production method of a compound represented by the formula (1):
- wherein
- wherein X1 and X2 are each independently a halogen atom,
- is a single bond or a double bond,
- R1 is an alkyl group optionally having substituent(s), an alkenyl group optionally having substituent(s), an alkynyl group optionally having substituent(s), an aryl group optionally having substituent(s) or a heteroaryl group optionally having substituent(s),
- R2 is absent, or a hydrogen atom, an alkyl group optionally having substituent(s), an alkenyl group optionally having substituent(s), an alkynyl group optionally having substituent(s), an aryl group optionally having substituent(s) or a heteroaryl group optionally having substituent(s), and
- Z is an amino-protecting group, a sugar group or an alkyl group, or a salt thereof, which comprises a step of reacting a compound represented by the formula (a):
- wherein
- wherein X1 and X2 are each independently a halogen atom, and
- Z is an amino-protecting group, a sugar group or an alkyl group, or a salt thereof, with an organometallic reagent.
Dependencies are inferred from the claim text.