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US 2006/0234972 A1Published application
Compositions and their uses directed to thymus and activation-regulated chemokine (TARC)
AssigneeIsis Pharmaceuticals, Inc.
InventorsJames Karras, Kenneth Dobie
Life of this patent
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Abstract
Disclosed herein are compounds, compositions and methods for modulating the expression of TARC in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of TARC, airway hyperresponsiveness, and/or pulmonary inflammation.
Claims15
An antisense compound of 15 to 35 nucleobases targeted to a nucleic acid molecule encoding human TARC (SEQ ID NO:
- 1), wherein the compound is targeted to at least a 12-nucleobase portion of nucleotides 60 to 172;
- or 574 to 605 of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.