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US 2006/0234971 A1Published application
Calpains as targets for inhibition of prion propagation
AssigneeUniversity of Kentucky
InventorsGlenn Telling, Rodney Guttman
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Abstract
The present invention relates to methods for the inhibition of disease-associated prion formation and propagation. Such methods are based on inhibition of PrPSc cleavage, which prevents PrPSc accumulation and results in reduced prion titers. More particularly, the present invention relates to endoproteolytic cleavage of PrPSc by calpain, a calcium (Ca2+)-activated cysteine protease, and its inhibition.
Claims2
A method of treating prion related diseases in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a calpain inhibitor.
Dependencies are inferred from the claim text.