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AssigneeSylentis S.A.U.
InventorsAna Jimenez, Angela Sesto, Irene Gascon, Jose Roman
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The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
A method of treating an eye disorder with increased intraocular pressure (IOP) comprising administering to a patient in need thereof a short interfering nucleic acid molecule (siNA) in an amount that reduces IOP.
A pharmaceutical composition comprising an siNA having a nucleotide sequence selected from the group consisting of SEQ ID NOs:1-1829.
A pharmaceutical composition comprising an siNA that is 40 nucleotides or less comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs:1-1829.
An isolated nucleic acid molecule consisting essentially of an siNA having a nucleotide sequence selected from the group consisting of SEQ ID NOs:1-1829.
An isolated nucleic acid molecule consisting essentially of an siNA that is 40 nucleotides or less and comprises a nucleotide sequence selected from the group consisting of SEQ ID NOs:1-1829.
Dependencies are inferred from the claim text.