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AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsWarren Strober, Kazuhiko Nakamura, Atsushi Kitani, Ivan Fuss Jr.
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The present invention provides alternatives to traditional drug and surgical treatments for IBD. In particular, the present invention provides compositions and methods for the treatment of autoimmune diseases such as IBD in humans using TGF-β therapy. The compositions of the present invention provide vectors containing TGF-β under the control of an inducible promoter. In particularly preferred embodiments, the present invention provides regulated plasmid constructs capable of inducing TGF-β production. In preferred embodiments, the methods of the present invention utilize the vectors described for assaying the expression of a gene in a cell. In some preferred embodiments, the methods of the present invention utilize the administration of TGF-β containing vectors to treat IBD. In alternative preferred embodiments, the present invention provides methods and compositions for the induction of high-level interleukin (e.g., IL-10) production.
A composition comprising a vector, wherein said vector further comprises a gene encoding a regulatory transcription factor which is under the control of a first promoter and a nucleic acid sequence of SEQ ID NO:1, wherein said nucleic acid sequence is under the control of a second promoter.
A composition comprising a vector wherein said vector further comprises a gene encoding a regulatory transcription factor which is under the control of a first promoter and a nucleic acid sequence selected from the group consisting of SEQ ID NO:1, variants of SEQ ID NO:1;
A method for expression of a polypeptide comprising:
A method for expression of a polypeptide comprising:
A composition comprising a vector, wherein said vector comprises a gene encoding a regulatory transcription factor which is under the control of a first promoter, and a gene encoding a TGF-β polypeptide which is under the control of a second promoter, wherein said second promoter is inducible.
A method for the expression of a polypeptide encoding a TGF-β polypeptide comprising the steps of:
Dependencies are inferred from the claim text.