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OwnerZhongmin Wang, Joseph Ho +1inventors
InventorsZhongmin Wang, Joseph Ho, Daniel Carter
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A method is provided for increasing the safety and efficacy of albumin-binding drugs such as those used as anti-cancer, anti-infective, or anti-hypertensive drugs, or for numerous other conditions. In the preferred method, the invention modulates those drugs which bind at the IB site on human serum albumin by co-administering a compound which is highly tolerable to humans and which can bind competitively with those albumin-binding drugs at the IB binding site so as to increase the safety and efficacy of the drug. The invention is advantageous in that by administering the highly tolerable compound in a sufficient amount to compete with the targeted drug, the latter can be administered at a much lower dosage while maintaining or exceeding its potency. Compositions containing the combination of highly tolerable compound and albumin-bind drugs are also disclosed.
A method for maximizing the therapeutic effectiveness of a drug that reduces the level of rapidly dividing cells in a patient in need thereof and that binds at the IB site of human serum albumin comprising co-administering a compound that binds competitively with said drug at the IB site of human serum albumin in an amount effective to maximize the therapeutic effectiveness of said drug in the patient.
A method for increasing the free concentration of a drug that reduces the level of rapidly dividing cells in a patient in need thereof and that binds at the IB site of human serum albumin comprising administering the drug in the presence of a compound that binds competitively with said drug at the IB site of human serum albumin in an amount effective to increase the free concentration of said drug in the bloodstream of the patient.
A therapeutic composition for reducing the level of rapidly cells in a patient in need thereof, comprising a drug that reduces the level of rapidly dividing cells in a patient and that binds to human serum albumin at the IB site and a compound that competitively binds to human serum albumin in an amount effective to increase or mudulate the free concentration of the drug in the bloodstream of a patient in need.
A method for maximizing the therapeutic effectiveness of a drug that reduces hypertension comprising administering an anti-hypertensive drug that binds to human serum albumin at the IB site along with a compound that binds competitively with said drug at the IB site of human serum albumin in an amount effective to manage the reduction of hypertension in the patient.
A method of maximizing the therapeutic effectiveness of an anti-infective drug that binds to the IB site of human serum albumin comprising administering with said drug a compound that binds competitively with said drug at the IB site of human serum albumin in an amount effective to maximize the effectiveness of the anti-infective drug.
Dependencies are inferred from the claim text.