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AssigneeAmersen Bioscience International, Inc.
InventorsHui-Ling Chen, Ying-Ming Huang, Ching-Te Chang, Wen-Yi Chuang
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The present invention relates to a series of dicarboxylic acid ester derivatives of ginsenosides such as succinate and glutarate derivatives of 20-O-β-D-glucopyranosyl-protopanaxadiol (compound K, abbreviated as CK), preparation thereof and pharmaceutical uses thereof. The dicarboxylic acid ester derivatives of ginsenosides of the present invention can be used to form pharmaceutical acceptable salts thereof having a high water solubility or can be directly dissolved in an aqueous solution of metal salt, and retain the pharmaceutical activities of ginsenosides such as tumor growth inhibition and cancer preventive cytotoxicity. The dicarboxylic acid ester derivatives of ginsenosides of the present invention are thus suitable for use in the manufactures of various pharmaceutically and cosmetically acceptable dosage forms of preparations, such as peripheral, oral, and topical dosage forms.
A dicarboxylic acid ester of ginsenoside.
A pharmaceutical preparation comprising an aqueous solution and a dicarboxylic acid ester of ginsenoside, or a pharmaceutically acceptable salt thereof, which is dissolved in said aqueous solution.
A method for treating a tumor, said method comprising admninistering to a subject in need of treatment a dicarboxylic acid ester of ginsenoside, or a pharmaceutically acceptable salt thereof, in an amount effective to treat said tumor.
A method for preparing a dicarboxylic acid ester of ginsenoside comprising reacting a ginsenoside with an activated dicarboxylic acid derivative in a solvent and in the presence of a catalyst to form a dicarboxylic acid ester of ginsenoside.
Dependencies are inferred from the claim text.