Combination therapy for effecting weight loss and treating obesity

A method for effecting weight loss in a subject comprising administering to the subject a combination of:

• (a) a therapeutically effective amount of a sympathomimetic agent selected from phenylethylamine, epinephrine, norepinephrine, epinine, dopamine, dabutamine, nordefrin, ethylnorepinephrine, isoproterenol, protokylol, isoetharine, metaproterenol, terbutaline, metaraminol, phenylephrine, tyramine, hydroxyamphetamine, methoxyphenamine, methoxamine, albuterol, amphetamine, methamphetamine, benzphetamine, ephedrine, pseudoephedrine, phenylpropanolamine, mephentermine, phentermine, chlorphentermine, fenfluramine, tuaminoheptane, propylhexedrine, diethylpropion, phenmetrazine, phendimetrazine, and methylphenidate, and (b) a therapeutically effective amount of an anticonvulsant sulfamate derivative having the structure of formula I
• wherein X is CH2 or O, R1, R2, R3, R4, and R5 are independently H or C1-C4 alkyl, and further wherein when X is O, then R2 and R3, and/or R4 and R5, may be taken together to form a methylene dioxy linkage of the formula —O—CR6R7—O— in which R6 and R7 are independently H or C1-C3 alkyl, or may be taken together to form a cyclopentyl or cyclohexyl ring.