Combination therapy for effecting weight loss and treating obesity
AssigneeVivus, Inc.
InventorThomas Najarian
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Abstract
The present invention features a novel therapy for effecting weight loss which involves treating a subject with a sympathomimetic agent (e.g., phentermine or a phentermine-like drug) in combination with an anticonvulsant sulfamate derivative (e.g., topiramate) such that the subject experiences weight loss. The combination methods of the present invention also are effective against symptoms associated with Syndrome X. The invention also features pharmaceutical compositions and kits for use in the practice of these novel therapies.
Claims24
A method for effecting a weight loss in a subject in need thereof comprising administering to said subject continually over a significant period of time an 8 mg daily dose of phentermine and in combination therewith a daily amount of topiramate selected to prevent the loss of effectiveness of phentermine alone.
A method for effecting weight loss in a subject in need thereof comprising administering to said subject continuously over a significant period of time a 10 mg daily dose of phentermine and in combination therewith a daily amount of topiramate selected to prevent the loss of effectiveness of phentermine alone.
A method for effecting weight loss in a subject in need thereof comprising administering to said subject continuously over a significant period of time a 15 mg daily dose of phentermine and in combination therewith a daily amount of topiramate selected to prevent the loss of effectiveness of phentermine alone.
A method for effecting weight loss in a subject in need thereof comprising administering to said subject continuously over a significant period of time a 20 mg daily dose of phentermine and in combination therewith a daily amount of topiramate selected to prevent the loss of effectiveness of phentermine alone.
Dependencies are inferred from the claim text.