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US 2006/0234949 A1Published application
Adduct of topiramate and tramadol hydrochloride and uses thereof
AssigneeCilag GmbH International
InventorsRainer Naeff, Sonja Spycher-Huber, Thomas Hunziker, Guenter Laufer
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Abstract
This invention relates to a new pharmaceutically useful compound which is a stoichiometrically 1:1 adduct of tramadol hydrochloride and topiramate, and to the manufacture and use thereof.
Claims11
A chemical compound which is the 1:1 adduct of topiramate and tramadol hydrochloride.
A process for preparing enantiomerically enriched mixtures of 1S,2S-tramadol hydrochloride, comprising:
- (a) disolving topiramate and tramadol hydrochloride in an appropriate solvent which is brought to elevated temperatures and then cooled to a temperature which is below room temperature and letting the adduct crystallize
- (b) separating the crystals from the mother liquor by filtration
- (c) separating the 1S,2S-tramadol hydrochloride from the mother liquor.
Dependencies are inferred from the claim text.