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US 2006/0234937 A1Published application
Modulation of angiogenesis
AssigneeMedical Research Council
InventorsTerence Rabbitts, Yoshihiro Yamada
Life of this patent
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Abstract
Substances are provided that are capable of modulating angiogenesis mediated by Lmo2 or a functionally related polypeptide, which substance binds to Lmo2 and/or a functionally related polypeptide, or alters the expression of Lmo2 or a functionally related polypeptide in a cell. Assay methods are provided for identifying such substances.
Claims16
1:
- A method of modulating angiogenesis in a mammal, comprising administering a substance to the mammal that modulates the expression and/or function of Lmo2 or a functionally related polypeptide, wherein angiogenesis is inhibited.
2:
- A method according to claim 1, wherein the expression and/or function of the Lmo2 or functionally related polypeptide is inhibited.
3:
- A method according to claim 1, wherein angiogenesis is inhibited in a specific tissue of said mammal.
4:
- A method for inhibiting the contribution of a cell to a process of angiogenesis in a mammal, comprising administering a substance that inhibits the expression of Lmo2 in said cell.
5:
- A method according to claim 1, wherein said substance is identified by a method comprising:
- contacting Lmo2 and/or the functionally related polypeptide with a candidate substance, and
- determining whether the angiogenesis mediating activity of Lmo2 or the functionally related polypeptide is inhibited.
6:
- A method according to claim 5, wherein said substance binds to the Lmo2 or the functionally related polypeptide.
7:
- A method according to claim 5, wherein said substance affects the interaction between the Lmo2 and the functionally related polypeptide.
8:
- A method according to claim 5, wherein said substance down regulates the expression of the Lmo2 or the functionally related polypeptide.
9:
- A method according to claim 5, wherein said substance inhibits the function of the Lmo2 or the functionally related polypeptide.
10:
- A method according to any one of claims 5 or 6-9, wherein the Lmo2 or the functionally related polypeptide is expressed on a cell.
11:
- A method according to claim 5, wherein the functionally related polypeptide is a Lmo2 binding partner.
12:
- A method according to claim 6, wherein the functionally related polypeptide is a Lmo2 binding partner.
13:
- A method according to claim 7, wherein the functionally related polypeptide is a Lmo2 binding partner.
14:
- A method according to claim 8, wherein the functionally related polypeptide is a Lmo2 binding partner.
15:
- A method according to claim 9, wherein the functionally related polypeptide is a Lmo2 binding partner.
16:
- A method according to claim 10, wherein the functionally related polypeptide is a Lmo2 binding partner.