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AssigneeNippon Medical School Foundation
InventorsShigeo Ohta, Sadamitsu Asoh
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The present invention provides a protein having a potent cell-death inducing activity that is, a fused protein is in which a modified Bax protein fused with GFP at the N-terminus and is further fused with a homing signal peptide having a homing activity specific for endothelial cells in tumor angiogenesis; a gene coding the fused protein; and a cancer cell growth inhibitor containing the fused protein. Namely, a fused gene containing a cell death-inducing gene acting specially on cancer tissue, which is a fused gene having a gene encoding a homing signal peptide sequence specific for endothelial cells undergoing angiogenesis, a gene encoding a green fluorescent protein (GFP) and a gene encoding ΔNBax protein, which is human Bax with a deletion of the N-terminal sequence containing the BH3 domain in this order, and a fusion protein encoded by the fused gene.
A fusion gene comprising a cell death-inducing gene that acts specifically on a surface receptor of endothelial cells undergoing angiogenesis, wherein the fusion gene is produced by fusing, a gene that codes for a homing signal peptide sequence specific for the surface receptor of endothelial cells undergoing angiogenesis, a gene coding for green fluorescent protein (GFP) and a gene coding for ΔNBax protein, which is human Bax with a deletion of the N-terminal sequence including the BH3 domain, in this order.
A fusion protein containing a cell death-inducing protein that acts specifically on surface receptor of endothelial cells undergoing angiogenesis, wherein the fusion protein is generated by fusing, a homing signal peptide sequence specific for a surface receptor of endothelial cells undergoing angiogenesis, green fluorescent protein (GFP) and ΔNBax protein, which is human Bax with a deletion of the N-terminal sequence containing the BH3 domain, in this order.
Dependencies are inferred from the claim text.