Loading patent…
OwnerW. Garvey, Yuchang Fu +1inventors
InventorsW. Garvey, Yuchang Fu, Mitchell Martin
Estimating the term…
The MINOR and TR3 genes are disclosed to be insulin responsive genes differentially expressed as a function of insulin resistance and Type 2 Diabetes in humans and a variety of well characterized animal models. The present disclosure shows that MINOR and TR3 have a functional role in insulin resistance. Therefore, MINOR and TR3 are attractive and novel therapeutic targets for combating insulin resistance and/or disease states and conditions characterized by insulin resistance. Correlation of insulin resistance and disease states and conditions characterized by insulin resistance, including Type II diabetes, with MINOR and TR3 gene expression are also disclosed. Methods of diagnosis, treatment and prevention are likewise disclosed for the treatment and/or prevention of insulin resistance and disease states or conditions characterized by insulin resistance.
A method for treating or preventing insulin resistance in a subject, said method comprising identifying a subject in need of said treatment or prevention and activating an insulin responsive gene selected from the group consisting of MINOR, TR3 and MINOR and TR3.
A method for treating or preventing a disease state associated insulin resistance in a subject, said method comprising identifying a subject in need of said treatment or prevention and activating an insulin responsive gene selected from the group consisting of MINOR, TR3 and MINOR and TR3.
A method for identifying a compound which activates an insulin responsive gene, said method comprising:
A method for identifying a compound useful for the treatment or prevention of insulin resistance, said method comprising the step of determining whether the compound interacts with the polypeptide product of a gene selected from the group consisting of:
A method for identifying a compound useful for the treatment or prevention of insulin resistance, said method comprising the step of determining whether the compound activates a gene selected from the group consisting of:
A method for identifying a compound useful for the treatment or prevention of a disease state associated with insulin resistance, said method comprising the step of determining whether the compound interacts with the polypeptide product of a gene selected from the group consisting of:
A method for identifying a compound useful for the treatment or prevention of a disease state associated with insulin resistance, said method comprising the step of determining whether the compound activates a gene selected from the group consisting of:
Dependencies are inferred from the claim text.