Methods for improving the structure and function of arterioles
AssigneeThe Regents of the University of California
InventorAlan Fogelman
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Abstract
The present invention relates to the unexpected finding that vessels smaller than even the smallest arteries (i.e. arterioles) thicken, become dysfunctional and cause end organ damage to tissues as diverse as the brain and the kidney. This invention provides a method to improve the structure and function of arterioles and preserve the function of end organs such as the brain and kidney.
Claims23
A method of improving arteriole structure and/or function, said method comprising:
- administering to a mammal in need thereof one or more of the active agents described in Tables 1-14 and/or a small organic molecule as described herein in a dosage sufficient to improve arteriole structure or function.
An active agent as described in Tables 1-14 and/or a small organic molecule as described herein for use in the prophylaxis or treatment of arterioles having impaired structure or function.
The use of an active agent as described in Tables 1-14 and/or a small organic molecule as described herein for the manufacture of a medicament for the prophylaxis or treatment of arterioles having impaired structure or function.
A kit for the treatment of a condition characterized by abnormal arteriole structure or function, said kit comprising:
- a container containing one or more of the active agents described in Tables 1-14 and/or a small organic molecule as described herein;
- and
- instructional materials teaching the use of the active agent(s) in the treatment of a condition characterized by abnormal arteriole structure or function.
Dependencies are inferred from the claim text.