Use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division
OwnerSergey Doronin, Ira Cohen +4inventors
InventorsSergey Doronin, Ira Cohen, Peter Brink, Glenn Gaudette, Michael Rosen, Richard Robinson
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Abstract
A method for treating a subject afflicted with a cardiac disorder, in vivo, comprising (i) producing a solution comprising media conditioned from the culture of cells, in vitro, and (ii) administering the solution of step (i) to the subject, thereby treating the cardiac disorder in the subject. Methods for determining whether an agent stimulates or inhibits myocyte proliferation.
Claims33
A method for regenerating myocardium in a mammal, comprising:
- delivering cells to the myocardium that induce native myocytes to enter the cell cycle.
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A method for regenerating myocardium in a mammal, comprising:
- attracting native stem cells to the myocardium that induce native myocytes to enter the cell cycle.
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A solution that induces myocyte proliferation, comprising at least one of (i) media conditioned by stem cells and (ii) media conditioned by myocytes and stem cells when they are co-cultured together.
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A method for treating a subject afflicted with a cardiac disorder, in vivo, comprising (i) producing a solution comprising media conditioned from the culture of cells, in vitro, and (ii) administering the solution of step (i) to the subject, thereby treating the cardiac disorder in the subject.
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Dependencies are inferred from the claim text.