Methylotrophic bacterium for the production of recombinant proteins and other products

A method of producing a recombinant peptide, a recombinant protein or a product from metabolic engineering using a genetically modified methylotrophic bacterium under the control of a regulated promoter from a methylotrophic microorganism of the same or different species as the methylotrophic bacterium, said method comprising the steps of:

• a) introducing into said methylotrophic bacterium an expression vector comprising a polynucleotide sequence, coding for a peptide or a protein under the control of a regulated promoter for allowing production of said peptide or protein or for allowing production of a product from metabolic engineering;
• and
• b) growing said genetically modified methylotrophic bacterium in a minimal salts medium lacking organic sugars and containing methanol as a source of carbon and energy for said bacterium for a time sufficient to allow production of said peptide or protein or said product from metabolic engineering.