US 2006/0234319 A1 · Disease determination method, data generation method for disease determination and data generation system for disease determination

Abstract

Supernatant of the urinary sample (SP1) was mixed with an acid or alkali and heated (SP2) and the sample for fluorescence assay was prepared after adjusting its acidity to alkaline (SP3). Next, using fluorometry, three-dimensional fluorescence spectrum consisted of an excitation light wavelength, fluorescence wavelength and fluorescence intensity (SP4). Then, a relative maximum peak is detected as a specific point in the three-dimensional fluorescence spectrum to specify a specific point attribute (peak number, peak position and fluorescence intensity) and then the urinary sample is sorted based on the attribute (SP5). Finally, the presence or absence of a disease such as a malignant tumor is determined based on the sorting results of the urinary sample (P6).

Claims32

Dependent claims

Disease determination method for determining whether a person has a certain disease or not using a biological sample, comprising;

pretreatment process to add an acidic or alkaline solution to the sample and to heat the sample,
excitation light irradiation process to irradiate the sample with excitation light and to continuously or intermittently change the wavelength of the excitation light,
emission light measurement process to measure the wavelength and intensity of the emission light emitted from the sample in response to the excitation light,
analyzing and sorting process to detect a specific point in the three-dimensional optical spectrum composed of the excitation light wavelength, emission light wavelength and emission light intensity and to sort or hierarchize the sample based on the specific point attribute, and
determination process to determine the presence or absence of the disease or the condition of the disease of the body to which the sample belongs based on the sorting and hierarchization results of the sample.

2 more elements

The data generation system for disease determination for generating disease determination data by analyzing the sample collected from the body of the subject, comprising,

excitation light irradiation means to irradiate the sample with the excitation light and to continuously or intermittently change the wavelength of the excitation light,
emission light measurement means to measure the wavelength and intensity of the emission light emitted from the sample in response to the excitation light, and
analyzing and sorting means to detect a specific point in the three-dimensional optical spectrum composed of the excitation light wavelength, emission light wavelength and emission light intensity and to sort or hierarchize the sample based on the specific point attribute to generate sorting data for disease determination.

Dependencies are inferred from the claim text.

Disease determination method, data generation method for disease determination and data generation system for disease determination

Life of this patent

Disease determination method, data generation method for disease determination and data generation system for disease determination

Life of this patent

Abstract

Claims32