Methods for distinguishing type-1 from type-2 diabetes
OwnerDavid Wagnerinventor
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Abstract
The present invention provides a new method for the prediction of, or diagnosis of, auto-immune diseases, thereby alerting the subject to the presence of, or propensity to develop, an auto-immune disease so that preventative or therapeutic regiments may be initiated or changed so as to treat, modulate or prevent expansion of the CD4loCD40hi T cell population responsible for the destructive inflammation. The invention also discloses agents which modulate, treat or prevent expansion of CD4loCD40hi T cells. In one embodiment, the method is predictive of type 1 diabetes. Furthermore, the present invention provides a new method for distinguishing type 1 from type 2 diabetes.
Claims13
A method of determining whether a subject has type 1 diabetes or type 2 diabetes comprising:
- a) obtaining a blood sample from the subject;
- b) detecting CD4+CD40+ T cells in the blood sample;
- c) determining whether the CD4+CD40+ T cells in the blood sample are expanded by comparing to CD4+CD40+ T cells in a control sample of blood, wherein an expanded level of CD4+CD40+ T cells indicates that the subject has type 1 diabetes.
A kit for determining whether a subject has type 1 diabetes or type 2 diabetes comprising:
- a control blood sample, means for obtaining blood sample from the subject, means for detecting CD4+CD40+ T cells, and a means for determining whether the CD4+CD40+ T cells in the blood sample from the subject are expanded.
Dependencies are inferred from the claim text.