Markers for sudden death in heart failure
OwnerRobert MacFadyen, Allan Struthersinventors
Life of this patent
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Abstract
A method for screening, diagnosis or prognosis of sudden death in heart failure in a mammalian subject, for determining sudden death in heart failure in a mammalian subject, for identifying a mammalian subject at risk of sudden death in heart failure, or for monitoring the effect of therapy administered to a mammalian subject at experiencing imminent sudden death in heart failure included measuring the level of C-reactive protein (CRP), myeloperoxidase (MPO), neutrophil count, white blood cell count and BNP in a sample of bodily fluid from the mammalian subject. Methods for monitoring the cardiac health of a mammalian subject are further included. Kits and devices for carrying out such methods are also provided.
Claims76
A method for screening or diagnosing sudden death in heart failure in a mammalian subject, for determining sudden death in heart failure, for identifying a mammalian subject at risk for sudden death in heart failure or for monitoring the effect of therapy administered to a mammalian subject experiencing imminent sudden death in heart failure, said method comprising:
- measuring a level of a first marker in a sample from the mammalian subject, wherein the first marker is C-reactive protein or neutrophil count;
- and
- associating the level of the first marker with a status of cardiac health.
A method for screening or diagnosing sudden death in heart failure in a mammalian subject, for determining sudden death in heart failure, for identifying a mammalian subject at risk of sudden death in heart failure, or for monitoring the effect of therapy administered to a mammalian subject experiencing imminent sudden death in heart failure, said method comprising
- measuring a level of a first marker in a sample from the mammalian subject, wherein the first marker is a neutrophil count;
- and
- associating the level of the first marker with a status of cardiac health.
A kit for screening, diagnosis or prognosis of sudden death in heart failure in a mammalian subject, for determining sudden death in heart failure, for identifying a mammalian subject at risk of sudden death in heart failure, or for monitoring the effect of therapy administered to a mammalian subject at experiencing imminent sudden death in heart failure, the kit comprising:
- instructions for taking a sample from said mammalian subject and associating the level of C-reactive protein with the status of cardiac health;
- one or more reagents for measuring the level of C-reactive protein in the sample.
A method of monitoring the health of a mammalian subject comprising measuring the level of a first marker in a sample from said mammalian subject, wherein said first marker is C-reactive protein or neutrophil count, and associating the level of the first marker with the status of cardiac health.
A system for monitoring cardiac health, comprising:
- a cartridge including a sample port and a first assay, wherein the first assay recognizes a first marker;
- and
- a cartridge reader including a detector configured to measure a level of the first marker recognized by the assay.
Dependencies are inferred from the claim text.