Diagnosis of acute myocardial, ischemic diseases
AssigneeRoche Diagnostics Operations, Inc.
InventorsIldiko Amann-Zalan, Jurgen Spinke
Life of this patent
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Abstract
A method for the diagnosis of acute myocardial, ischaemic diseases, for example acute myocardial infarct, particularly without increasing ST-paths in EKG (NSTEMI). At least two markers on a patient, who is to examined, are determined. A kit for carrying out said diagnostic method, including a test strip for carrying out quick tests.
Claims21
A method for diagnosing acute myocardial, ischemic diseases in a patient, the method comprising determining in at least one patient sample:
- (a) a cardiospecific neurohormonal marker, and
- (b) at least one of
- (i) a non-cardiospecific ischemic marker selected from the group consisting of ischemia-modified albumin (IMA), fatty acid, pregnancy associated plasma protein A, and sphingosine-1-phosphate, and
- (ii) a non-cardiospecific muscle-specific marker,
- and relating the presence or amount of markers (a) and (b) in the at least one patient sample to the risk or severity of acute myocardial, ischemic disease in the patient.
A reagent kit for the diagnosis of acute myocardial, ischemic diseases, the kit comprising detection reagents for determining (a) a cardiospecific neurohormonal marker, and (b) at least one of (i) a non-cardiospecific ischemic marker selected from the group consisting of ischemia-modified albumin (IMA), fatty acid, pregnancy associated plasma protein A, and sphingosine-1-phosphate, and (ii) a non-cardiospecific muscle-specific marker.
A reagent kit for diagnosing acute myocardial, ischemic diseases, comprising at least one test strip comprising reagents for determining (a) at least one of BNP and NP-proBNP, and (b) IMA.
Dependencies are inferred from the claim text.