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US 2006/0234295 A1Published application
Sandwich immunoassay for identifying partial proanp peptides
AssigneeB.R.A.H.M.S GmbH
InventorsAndreas Bergmann, Joachim Struck
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Abstract
Disclosed is an improved sandwich immunoassay for identifying partial proANP peptides in cardiac and sepsis diagnosis by using two antibodies which specifically bond to partial sequences in the mid-regional area of NT-proANP, extending from amino acid 53 to amino acid 83 of NT-proANP.
Claims13
Method for identifying proANP (SEQ ID NO:2) or partial peptides formed therefrom, which are not the C-terminal ANP (99-125;
- “ANP”), in biological fluids for medical diagnosis, prognosis and therapy-accompanying monitoring by means of a sandwich immunoassay (two-sided immunoassay) using two antibodies which bind specifically to different partial sequences of N-terminal proANP (NT-proANP;
- proANP 1-98;
- SEQ ID NO:
- 1), characterized in that both antibodies bind to partial sequences in the midregional area of NT-proANP which extends from amino acid 50 to amino acid 90 (SEQ ID NO:1;
- SEQ ID NO:2) of NT-proANP.
2 more elements
Dependencies are inferred from the claim text.