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OwnerChing Chung, Lily Chan +6inventors
InventorsChing Chung, Lily Chan, Keli Ou, Shao-En Ong, Teck Seow, Cynthia M.Y. Liang, Meng Choong, Li Tan
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The present invention relates generally to the identification of the products of gene expression in cancerous tissue or other tissue associated with an aberrant medical condition. Identification of such expression products enables the development of a range of diagnostic and therapeutic agents. In one embodiment of the present invention, a gene is differentially or preferentially expressed in cancerous tissue relative to normal tissue. Identification of the expression product of the gene and of the gene itself provides a means of developing diagnostic and therapeutic agents for the treatment, prophylaxis, and diagnosis of the cancerous condition in which the gene is differentially or preferentially expressed.
A method for diagnosing human hepatocellular carcinoma or a related condition in a subject or a propensity for said subject to develop human hepatocellular carcinoma or a related condition, said method comprising the step of
A modulator of expression of a nucleic acid molecule, which nucleic acid molecule is differentially or preferentially expressed in human hepatocellular carcinoma tissue or tissue from a related cancer relative to other tissue in said subject and/or in subjects not diagnosed with this condition, that decreases the expression of said nucleic acid molecule.
A method of modulating one or more activities within a cell, said method comprising the step of
A method of treating hepatocellular carcinoma or a related condition, said method comprising the step of administering to a subject in need of such treatment an antagonist of a gene or gene product which is differentially or preferentially expressed in tissue from subjects with hepatocellular carcinoma or a related condition relative to other tissue in said subject and/or subjects not diagnosed with this condition.
An isolated peptide, polypeptide, or protein, or a derivative, homologue, or analogue thereof, which protein is differentially or preferentially produced in or by human hepatocellular carcinoma tissue or tissue from a related cancer relative to other tissue in said subject and/or in subjects not diagnosed with this condition.
Dependencies are inferred from the claim text.