Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto
AssigneeThe Burnham Institute
InventorsJohn Reed, Shu-ichi Matsuzawa
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Abstract
In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein.
Claims11
Isolated nucleic acid encoding a Siah-Mediated-Degradation-Protein (SMDP) and/or SFC-Complex-Protein (SCP), or a functional fragment thereof.
Isolated nucleic acid encoding Siah-Mediated-Degradation-Protein (SMDP) and/or SFC-Complex-Protein (SCP), or functional fragments thereof, selected from:
- (a) DNA encoding the amino acid sequence set forth in SEQ ID Nos:2, 4, 6, 8, 10, 12 or 14, or
- (b) DNA that hybridizes to the DNA of (a) under moderately stringent conditions, wherein said DNA encodes biologically active SMDP and/or SCP, or
- (c) DNA degenerate with respect to either (a) or (b) above, wherein said DNA encodes biologically active SMDP and/or SCP.
9-17. (canceled)
19-46. (canceled)
Dependencies are inferred from the claim text.