Human paris-1 antigen and nucleic acids: diagnostic and therapeutic uses
AssigneeNorthwest Biotherapeutics, Inc.
InventorYaling Zhou
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Abstract
The present invention relates to the discovery, identification and characterization of a novel tumor suppressor gene designated PARIS-1. The invention includes nucleotide sequences of the PARIS-1 gene and amino acid sequences of its encoded protein product(s), as well as fragments, derivatives and analogs thereof. The invention also includes the production of PARIS-1 proteins, fragments and derivatives and of antibodies specific for PARIS-1 gene products. The invention further comprises agents and compositions which can modulate the expression of PARIS-1 or PARIS-1 expression products to effect the proliferation of cells which express PARIS-1. One particular embodiment comprises agents and compounds which can slow or ablate the proliferation of prostate tumor cells.
Claims8
An antibody which can immunospecifically bind a PARIS-1 protein or fragment thereof.
A composition comprising an amount of PARIS-1 protein, or a fragment thereof, which can effectively modulate cell proliferation and a pharmaceutically acceptable carrier.
A composition comprising an amount of an antigen binding fragment or derivative of an antibody immunospecific for PARIS-1 protein and a pharmaceutically acceptable carrier.
A method for decreasing the rate of proliferation of a cell which expresses PARIS-1 in a subject comprising administering an amount of an agent which effectively modulates PARIS-1 activity to modulate cell proliferation.
Dependencies are inferred from the claim text.