Tumor Necrosis Factor Receptors 6 Alpha & 6 Beta
AssigneeHuman Genome Sciences, Inc.
InventorsReiner Gentz, Guo-Liang Yu, Jian Ni, Reinhard Ebner, Ping Feng, Steven Ruben
Life of this patent
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Abstract
The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
Claims18
A method of treating or preventing an inflammatory disease or disorder, inflammation, an autoimmune disease or disorder, graft versus host disease (GVHD), allergy, asthma, or hepatitis comprising administering to an animal a therapeutically effective amount of a protein selected from the group consisting of:
- (a) a protein whose sequence comprises amino acid residues 1 to 300 of SEQ ID NO:2;
- (b) a protein whose sequence comprises amino acid residues 30 to 300 of SEQ ID NO:2;
- (c) a protein whose sequence comprises amino acid residues 31 to 283 of SEQ ID NO:2;
- (d) a protein whose sequence comprises amino acid residues 31 to 300 of SEQ ID NO:2;
- (e) a protein whose sequence comprises the amino acid sequence of the full-length polypeptide encoded by the cDNA contained in ATCC Deposit Number 97810;
- (f) a protein whose sequence comprises the amino acid sequence of the mature form of the polypeptide encoded by the cDNA contained in ATCC Deposit Number 97810;
- and
- (g) a protein whose sequence comprises the amino acid sequence of the extracellular domain of the polypeptide encoded by the cDNA contained in ATCC Deposit Number 97810.
An isolated nucleic acid molecule comprising a polynucleotide selected from the group consisting of:
- (a) a polynucleotide encoding amino acids residues 1-41 of SEQ ID NO:2 fused to amino acid residues 48-195 of SEQ ID NO:31 fused to amino acid residues 186-192 of SEQ ID NO:2;
- (b) a polynucleotide encoding a polypeptide comprising amino acids residues 1-294 of SEQ ID NO:2 fused to the amino acid sequence aspargine-isoleucine-threonine;
- (c) the polynucleotide of SEQ ID NO:28;
- (d) the polynucleotide of SEQ ID NO:32;
- and
- (e) the polynucleotide of SEQ ID NO:33.
A method of diagnosing a malignant tumor comprising determining the level of TNFR-6 alpha in the serum of a patient whereby a level of 20 picograms/milliliter is indicative of a tumor.
Dependencies are inferred from the claim text.