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US 2006/0234277 A1Published application
Method for selectively blocking hemoglobin RNA amplification
AssigneeAmgen Inc.
InventorsChris Russell, Keith Kerkof, Martin Timour
Life of this patent
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Abstract
This invention provides oligonucleotides, compositions, kits, and methods for specifically blocking amplification of hemoglobin mRNA in a sample of RNA. The oligonucleotides and methods are particularly advantageous for analyzing samples of RNA extracted from whole blood samples.
Claims17
An oligonucleotide comprising at least one modified locked nucleotide analog, wherein the oligonucleotide is between about 8 to about 30 nucleotides in length, and wherein the oligonucleotide hybridizes to the 3′ end of hemoglobin A mRNA transcript or hemoglobin B mRNA transcript to form a heat stable duplex.
Dependencies are inferred from the claim text.