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OwnerKenneth Polonsky, Yukio Horikawa +7inventors
InventorsKenneth Polonsky, Yukio Horikawa, Naohisa Oda, Nancy Cox, Seamus Sreenan, Yun-Ping Zhou, Kenichi Otani, Craig Hanis, Graeme Bell
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The present invention relates generally to the field of diabetes. More particularly, it concerns the identification of genes responsible for NIDDM1 for use in diagnostic and therapeutic applications. The present invention demonstrates that the NIDDM1 locus is, in fact, the calpain 10 gene. The invention further relates to the discovery that analysis of mutations in calpain genes and gene products can be diagnostic for type 2 diabetes. The invention also contemplates methods of treating diabetes in view of the fact that calpain mutations can cause diabetes. Further, the invention relates to novel polynucleotides of the NIDDM1 locus and polypeptides encoded by such polynucleotides.
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A method of modulating an insulin secretory response in an animal comprising the step of administering a modulator of calpain function to the animal.
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A method of modulating insulin mediated glucose transport in an animal comprising the step of administering a modulator of calpain function to the animal.
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A method of treating diabetes in an animal comprising the step of modulating calpain function in the animal by administering a modulator of calpain function to the animal.
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Dependencies are inferred from the claim text.