Using gene panels to predict tissue sensitivity to ionizing radiation

A method of predicting tissue sensitivity to radiation, comprising the steps of:

• selecting a panel of genes associated with increased chromosomal damage,
• selecting a panel of genes associated with reduced chromosomal damage,
• exposing the tissue to radiation,
• measuring RNA of the tissue, and
• predicting sensitivity to radiation using said panel of genes associated with increased chromosomal damage and said panel of genes associated with chromosomal damage.

A method of predicting tissue sensitivity to radiation, comprising the steps of:

• selecting at least two panels of genes associated with chromosomal damage,
• exposing the tissue to a priming dose of radiation,
• waiting for a time period,
• exposing the tissue to a challenge dose of radiation,
• waiting for another time period,
• measuring RNA of the tissue, and
• predicting sensitivity to radiation using the measured RNA of said step of measuring RNA of said two panels of genes in the tissue.

A method of using tissue for predicting sensitivity to radiation, comprising the steps of:

• selecting a first panel of genes associated with increased chromosomal damage,
• selecting a second panel of genes associated with reduced chromosomal damage,
• exposing the tissue to a priming dose of radiation,
• waiting for a time period and exposing the tissue to a challenge dose of radiation,
• waiting for a time period and measuring RNA of the tissue providing measured RNA of said first panel of genes associated with increased chromosomal damage and providing measured RNA of said second panel of genes associated with reduced chromosomal damage, and
• predicting sensitivity to radiation by comparing said measured RNA of said first panel of genes associated with increased chromosomal damage and said measured RNA of said second panel of genes associated with reduced chromosomal damage.