Double stranded RNA receptor (dsRNA-R) and methods relating thereto
AssigneeChiron Corporation
InventorMary Mackichan
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Abstract
The present invention is directed to nucleic acid molecules and polypeptides encoding a dsRNA receptor (dsRNA-R). The dsRNA-R contains a THD, interacts with the MyD88 adapter protein, and may bind to dsRNA. The present invention is also directed to antibodies against dsRNA-R and to methods of modulating an immune response and the methods of identifying compounds which bind to and/or modulate dsRNA-R.
Claims2
A method of identifying a compound which binds to a Toll-like receptor that binds dsRNA or modulates the ability of said receptor to bind dsRNA, wherein said receptor comprises a Toll Homology Domain that binds to MyD88, the method comprising:
- contacting said receptor, or cells expressing said receptor, with a compound;
- and
- determining whether said compound binds to or modulates the ability of said receptor to bind dsRNA.
A method of forming a receptor/ligand complex, the method comprising contacting a Toll-like receptor that binds dsRNA and that comprises a Toll Homology Domain that binds to MyD88, with a dsRNA under receptor/ligand binding conditions.
Dependencies are inferred from the claim text.