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US 2006/0234254 A1Published application
Colon cancer biomarker discovery
OwnerSungwhan An, Chiwang Yoon +4inventors
InventorsSungwhan An, Chiwang Yoon, Youngho Moon, Tae Oh, Dae Yoon, Myungsoon Kim
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Abstract
The present application discloses an epigenetic marker for colon cancer.
Claims19
A method for discovering a methylation marker gene for the conversion of a normal cell to colon cancer cell comprising:
- (i) comparing converted and unconverted cell gene expression content to identify a gene that is present in greater abundance in the unconverted cell;
- (ii) treating a converted cell with a demethylating agent and comparing its gene expression content with gene expression content of an untreated converted cell to identify a gene that is present in greater abundance in the cell treated with the demethylating agent;
- and
- (iii) identifying a gene that is common to the identified genes in steps (i) and (ii), wherein the common identified gene is the methylation marker gene.
1 more element
A method of diagnosing likelihood of developing colon cancer comprising assaying for methylation of a colon cancer specific marker gene in normal appearing bodily sample.
Dependencies are inferred from the claim text.