Modulation of insulin like growth factor i receptor expression

A method of screening for a modulator of IGF-1R gene expression, the method comprising the steps of:

• a. contacting a preferred target segment of a nucleic acid molecule encoding IGF-IR with one or more candidate modulators of IGF-IR expression, and
• b. identifying one or more modulators of IGF-IR expression which modulate the expression of the IGF-IR.

A diagnostic method for identifying a disease state comprising identifying the presence of IGF-IR in a sample using a compound comprising atleast an 8 nucleobase portion of sequence similarity with at least one of SEQ ID NO:

• 1 to SEQ ID NO:75 or SEQ ID NO:100 through 136.

A method of ameliorating the effects of psoriasis, said method comprising contacting proliferating skin or skin capable of proliferation with an effective amount of one or more phosphorothioate nucleic acid molecules or chemical analogs thereof capable of inhibiting or otherwise reducing IGF-I mediated cell proliferation wherein the nucleic acid molecules are selected from SEQ ID NO:1 through 75 and SEQ ID NO:100 through 136.

A composition comprising a phosphorothioate nucleic acid molecule capable of inhibiting or otherwise reducing IGF-I mediated cell proliferation or other medical disorder, said composition further comprising one or more pharmaceutically acceptable carriers and/or diluents.

Use of a phosphorothioate ASO directed to the gene encoding IGF-IR in the manufacture of a medicament in the treatment of proliferation and/or inflammation of keratinocyte cells.