Method of detecting gene polymorphism
OwnerYusuke Nakamura, Akihiro Sekine +2inventors
InventorsYusuke Nakamura, Akihiro Sekine, Aritoshi Iida, Susumu Saito
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Abstract
A method for detecting a genetic polymorphism(s) in a gene encoding cytochrome P450 using as oligonucleotide probes and/or oligonucleotide primers at least one sequence selected from the group consisting of an at least 13 nucleotide sequence within any of the nucleotide sequences as shown in SEQ ID NOS: 1 through 215, said at least 13 nucleotide sequence containing the 21st nucleotide, or a sequence complementary to said at least 13 nucleotide sequence.
Claims14
A method for detecting a genetic polymorphism(s) in a gene encoding cytochrome P450 using as oligonucleotide probes and/or oligonucleotide primers at least one sequence selected from the group consisting of an at least 13 nucleotide sequence within any of the nucleotide sequences as shown in SEQ ID NOS:
- 1 through 215, said at least 13 nucleotide sequence containing the 21st nucleotide, or a sequence complementary to said at least 13 nucleotide sequence.
A method for screening a drug, comprising comparing information about a polymorphism(s) in a gene encoding cytochrome P450 and/or a sequence complementary thereto with information about a polymorphism(s) in a gene encoding cytochrome P450 and/or a sequence complementary thereto obtained from a subject;
- analyzing the efficacy and/or safety of drugs metabolized by cytochrome P450;
- and selecting a drug to be used from the analysis results obtained.
An oligonucleotide selected from the group consisting of the nucleotide sequences as shown in SEQ ID NOS:
- 1 through 215 and sequences complementary thereto.
An oligonucleotide prepared so as to include a gene polymorphic site present in a gene encoding cytochrome P450 and/or a sequence complementary thereto based on the information about a polymorphism(s) in the gene and/or the complementary sequence thereto.
An oligonucleotide which is designed in a genomic DNA region containing a gene polymorphic site in any of the nucleotide sequences as shown in SEQ ID NOS:
- 1 through 215 so that it is located within 1000 bp of the polymorphic site toward the 5′-end and/or the 3′-end of the genomic DNA region, and which has a length of 13-60 nucleotides.
Dependencies are inferred from the claim text.