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US 2006/0234216 A9Published application
Haplotype structures of chromosome 21
AssigneePerlegen Sciences, Inc.
InventorsDavid Cox, Deana Arnold
Life of this patent
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Abstract
The present invention includes the use of any of the polymorphisms, SNP haplotype blocks or SNP haplotype patterns. In one embodiment, susceptibility to a phenotype resulting from an allele or marker in linkage disequilibrium with such polymorphic forms is evaluated. Novel therapeutic and diagnostic compounds and methods are also disclosed.
Claims27
An isolated nucleic acid molecule selected from the group consisting of:
- a) an isolated nucleic acid molecule comprising the sequence of SEQ ID NO:
- 1 provided that said nucleic acid molecule is not SEQ ID NO:
- 2;
- b) an isolated nucleic acid molecule comprising at least 10 nucleotides of SEQ ID NO:
- 1, wherein said nucleic acid molecule includes at least one alternative base as listed in FIG. 1 or FIG. 2;
- and
- c) an isolated nucleic acid molecule which is complementary to the isolated nucleic acid molecule of a) or b).
4 more elements
An isolated nucleic acid molecule comprising at least one nucleic acid segment of SEQ ID NO:
- 1, provided that said isolated nucleic acid molecule is not a segment of SEQ ID NO:
- 2, wherein said segment is selected from the group consisting of nucleotide positions 21302875 to 21340269 of SEQ ID NO:
- 1, nucleotide positions 21352474 to 21372019 of SEQ ID NO:
- 1, and nucleotide positions 21378872 to 21399221 of SEQ ID NO:
- 1.
2 more elements
A database comprising one or more SNP alleles of SEQ ID NO:
- 1, wherein said one or more SNP alleles is associated with a phenotypic trait;
- wherein said one or more SNP alleles has been derived from an analysis of a plurality of genomes;
- and wherein said database is on a computer-readable medium.
Dependencies are inferred from the claim text.