Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of an active agent
AssigneeNanoCyte Inc.
InventorsTamar Lotan, Shimon Eckhouse
Life of this patent
Estimating the term…
Abstract
Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of a pharmaceutical agent are described.
Claims47
A method of preconditioning a tissue prior to delivery of an active agent into and/or through the tissue, the method comprising:
- (a) administering onto said tissue at least one stinging capsule/cell;
- and
- (b) discharging said at least one stinging capsule/cell to thereby deliver tubule of said at least one stinging capsule/cell onto said tissue thus preconditioning said tissue for subsequent delivery of said active agent into and/or through said tissue.
A method of delivery of an active agent into and/or through a tissue, the method comprising:
- (a) preconditioning said tissue by:
- (i) administering onto said tissue at least one stinging capsule/cell;
- and
- (ii) discharging said at least one stinging capsule/cell to thereby deliver tubule of said at least one stinging capsule/cell onto said tissue thus preconditioning said tissue for subsequent delivery of the active agent into and/or through said tissue;
- and subsequently
- (b) administering the active agent onto said tissue, thereby effecting the delivery of the active agent into and/or through said tissue.
A pharmaceutical composition comprising at least one stinging capsule/cell and an orientation and proximity agent selected for:
- (i) positioning at least one stinging capsules/cells in intimate proximity with a tissue;
- and
- (ii) orientating said at least one stinging capsule/cell such that the opening tip of said stinging capsule substantially faces said tissue.
A method of orientating stinging capsules/cells with respect to a tissue, the method comprising contacting at least one stinging capsule/cell, an orientation and proximity agent and said tissue, wherein said orientation and proximity agent is selected for:
- (i) positioning said at least one stinging capsule/cell in intimate proximity with said tissue;
- and
- (ii) orientating said at least one stinging capsule/cell such that the opening tip of said stinging capsule substantially faces said tissue.
A device for delivery of an active agent, the device comprising:
- (i) a first compartment comprising at least one stinging cell/capsule;
- and
- (ii) a second compartment comprising an active agent.
Dependencies are inferred from the claim text.