Treatment of Human Multiple Myeloma by Curcumin
OwnerBharat Aggarwalinventor
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Abstract
All multiple myeloma cell lines examined showed constitutively active IκB kinase (IKK), IκBα phosphorylation and constitutively active NF-κB. Curcumin, a chemopreventive agent, suppressed constitutive IκBα phosphorylation through inhibition of IKK activity and downregulated NF-κB. Curcumin also downregulated expression of NF-κB-regulated gene products such as IκBα, Bcl-2, Bcl-xL, cyclin D1 and interleukin-6. Consequently, curcumin suppressed multiple myeloma cell proliferation and arrested cells at the G1/S phase of the cell cycle. Curcumin also induced apoptosis and chemosensitivity to vincristine. Overall, results presented herein provide a molecular basis for the treatment of multiple myeloma patients with this pharmacologically safe agent.
Claims11
1-13. (canceled)
A method of inducing chemosensitivity in chemoresistant multiple myeloma cells in vitro or in vivo, comprising contacting said cells with an amount of a curcuminoid effective to induce chemosensitivity in said cells.
A method of inducing chemosensitivity to one or more chemotherapeutic agents against multiple myeloma cells in a subject, comprising the steps of:
- a) administering to said subject a curcuminoid, and
- b) administering to said subject one or more chemotherapeutic agents,
- wherein said curcuminoid induces chemosensitivity to said one or more chemotherapeutic agents against multiple myeloma cells in said individual.
Dependencies are inferred from the claim text.