Intravenous nanoparticles for targeting drug delivery and sustained drug release
OwnerTsutomu Ishihara, Yutaka Mizushimainventors
Life of this patent
Estimating the term…
Abstract
Provided are poly(lactic-co-glycolic acid) (PLGA) and poly(lactic acid) (PLA) nanoparticles that encapsulate a low molecular weight and water-soluble drug and can deliver the drug to target legion sites where the particles gradually release the drug over a prolonged period of time. The nanoparticles are prepared by allowing the low-molecular, water-soluble and non-peptide drug to interact with a metal ion so as to make the drug hydrophobic, encapsulating the hydrophobicized drug into PLGA or PLA nanoparticles, and allowing a surfactant to be adsorbed onto the surface of the particles.
Claims18
Intravenous nanoparticles for targeting drug delivery and sustained drug release, characterized in that a low-molecular weight, water-soluble and non-peptide drug is made hydrophobic by metal ion and is encapsulated in nanoparticles formed with poly(lactic-co-glycolic acid) or poly(lactic acid), and a surfactant is applied to the surface of the nanoparticles of poly(lactic-co-glycolic acid) or poly(lactic acid).
A method for producing intravenous nanoparticles for targeting drug delivery and sustained drug release, comprising the steps of:
- hydrophobicizing a low-molecular weight, water-soluble and non-peptide drug by the use of metal ion;
- dissolving or suspending, along with a poly(lactic-co-glycolic acid) or a poly(lactic acid), the hydrophobicized drug in a water-miscible organic solvent;
- and
- adding the resulting solution or the suspension to an aqueous solution of a surfactant to apply the surfactant to the surface of the nanoparticles.
Dependencies are inferred from the claim text.